A10049
Niemann-Pick type C1 Like-1 Rabbit polyclonal antibody
Size
£152.00
- SKU:
- A10049
- Additional Names:
- LDLCQ7|Niemann-Pick type C1 Like-1|NPC11L1|SLC65A2
- Application:
- ELISA, WB
- Molecular Weight:
- 140kDa/150kDa
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Immunogen:
- Recombinant protein (or fragment).This information is considered to be commercially sensitive.
- Formulation:
- Unmodified
- Sequence:
- AAYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNV
- Uniprot:
- Q9UHC9
- Synonyms:
- LDLCQ7;niemann-Pick C1-like protein 1;NPC1 (Niemann-Pick disease, type C1, gene)-like 1;NPC1 like 1;NPC1-like intracellular cholesterol transporter 1;NPC11L1;SLC65A2
- Extra Details:
- The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice