D-K6L9
Product Sizes
1 mg
AM-370-1MG
About this Product
- SKU:
- AM-370
- Additional Names:
- AM-370, AM370, D-K6L9, Amp1D, Amphipathic 1D, LKLLKKLLKKLLKLL-NH2,|Amp1D, Amphipathic 1D
- Extra Details:
- D-K6L9 is a host defense-like peptide composed of six lysines and nine leucines, modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases. D-K6L9 shows antimicrobial and antibiofilm activities against Pseudomonas aeruginosa from cystic fibrosis patients without inducing bacterial resistance. In addition to its antimicrobial properties, in animal models D-K6L9 is able to target and arrest the growth of aggressive and hormone-resistant primary human prostate and breast tumours and prevent metastasis, effects which are correlated with increased necrosis of the tumour cells and a decrease in the tumour microvessel density. The selectivity of D-K6L9 derives from specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 1803.35
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides