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Proteins and Peptides

D-K6L9

Product Sizes
1 mg
AM-370-1MG
About this Product
SKU:
AM-370
Additional Names:
AM-370, AM370, D-K6L9, Amp1D, Amphipathic 1D, LKLLKKLLKKLLKLL-NH2,|Amp1D, Amphipathic 1D
Extra Details:
D-K6L9 is a host defense-like peptide composed of six lysines and nine leucines, modified by the inclusion of D-amino acids to improve antimicrobial activity and resistance to degradation by proteases. D-K6L9 shows antimicrobial and antibiofilm activities against Pseudomonas aeruginosa from cystic fibrosis patients without inducing bacterial resistance. In addition to its antimicrobial properties, in animal models D-K6L9 is able to target and arrest the growth of aggressive and hormone-resistant primary human prostate and breast tumours and prevent metastasis, effects which are correlated with increased necrosis of the tumour cells and a decrease in the tumour microvessel density. The selectivity of D-K6L9 derives from specific binding to surface phosphatidylserine and the killing of the cancer cells via cytoplasmic membrane depolarization.
Immunogen:
Antibacterials
Molecular Weight:
1803.35
Physical State:
Freeze dried solid
Purity:
>95%
Sequence:
H-Leu-Lys-(D)Leu-Leu-Lys-(D)Lys-Leu-(D)Leu-(D)Lys-Lys-Leu-Leu-(D)Lys-Leu-Leu-NH2
Shipping Conditions:
Blue Ice
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides