Elastase, Porcine
Product Sizes
250 units
16-19-051200-PORCINE-250UNITS
1000 units
16-19-051200-PORCINE-1000UNITS
10000 units
16-19-051200-PORCINE-10000UNITS
25000 units
16-19-051200-PORCINE-25000UNITS
About this Product
- SKU:
- 16-19-051200-PORCINE
- Additional Names:
- Cancer, Proteomics, In Vitro Diagnostics, Cancer, Diabetes, Cystic Fibrosis,|PPE, Pancreatopeptidase E
- Buffer:
- 2X crystallized preparation, lyophilized from 1 mM Acetic Acid and 50 mM Trehalose.
- CAS Number:
- 39445-21-1
- CE/IVD:
- RUO
- Extra Details:
- Elastase from porcine pancreas is a serine protease enzyme with a molecular weight of approximately 26 kDa, primarily responsible for hydrolyzing elastin-an essential protein in elastic fibers of connective tissue-as well as other substrates like hemoglobin, casein, and fibrin. It is synthesized in the pancreas and secreted into the intestine, where it breaks down dietary proteins during digestion. Elastase is unique among proteases for its ability to cleave native elastin, a property not shared by trypsin or chymotrypsin. Deficiency or dysfunction of pancreatic elastase is clinically significant, as it serves as a biomarker for exocrine pancreatic insufficiency (EPI), a condition marked by inadequate enzyme production leading to maldigestion, malabsorption, and symptoms such as steatorrhea, weight loss, and nutritional deficiencies. EPI is associated with diseases like chronic pancreatitis, cystic fibrosis, pancreatic cancer, diabetes, and celiac disease. In research and biotechnology, porcine pancreatic elastase is widely used for protein structural studies, tissue dissociation, and as a model enzyme in studies of extracellular matrix degradation and enzyme kinetics. Its robust activity and specificity make it valuable for in vitro assays and biomedical applications.
- Formulation:
- 2X crystallized preparation, lyophilized from 1 mM Acetic Acid and 50 mM Trehalose.
- Molecular Weight:
- 25,000 Da
- Physical State:
- Lyophilized
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Porcine pancreas was obtained from healthy animals of US origin and under the care of a registered veterinarian.
- Storage Conditions:
- -20[o]C
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
