Apolipoprotein B
Product Sizes
0.5 mg
16-16-120200-0.5MG
1 mg
16-16-120200-1MG
About this Product
- SKU:
- 16-16-120200
- Additional Names:
- ApoB, ApoB 100|In Vitro Diagnostic, Cardiovascular Research, Diabetes Research
- Buffer:
- Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCl.
- CE/IVD:
- RUO
- Extra Details:
- Apolipoprotein B (Apo B), the principal structural protein of LDL, VLDL, and chylomicrons, exists in two isoforms: Apo B-100 (4536 amino acids, liver-derived) and Apo B-48 (2152 amino acids, intestinal). Apo B-100 mediates LDL receptor binding, enabling cellular cholesterol uptake, while Apo B-48 facilitates dietary fat absorption via chylomicrons. Both isoforms stabilize lipoprotein particles and coordinate lipid transport through interactions with microsomal triglyceride transfer protein (MTP). Elevated Apo B levels (>90 mg/100 mL) directly correlate with atherosclerotic cardiovascular disease (ASCVD) risk, outperforming LDL cholesterol as a predictor due to its one-to-one association with atherogenic particles. Mutations like APOB R3500Q cause familial hypercholesterolemia, impairing LDL receptor binding and increasing circulating LDL, leading to premature ASCVD. Apo B also contributes to insulin resistance and metabolic syndrome through pro-inflammatory pathways. Clinically, Apo B serves as a nonfasting biomarker for residual cardiovascular risk, guiding therapies like mipomersen, an antisense oligonucleotide that reduces Apo B synthesis and LDL levels in refractory hypercholesterolemia. Emerging applications include targeting Apo B in lipoprotein(a) reduction and hepatic steatosis management.
- Formulation:
- Lyophilized from 10 mM Na deoxycholate, pH 10.0, with 50 mM Na2CO3 and 50 mM NaCl.
- Molecular Weight:
- 550,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
