Apolipoprotein AII
Product Sizes
0.5 mg
16-16-120102-0.5MG
1 mg
16-16-120102-1MG
10 mg
16-16-120102-10MG
About this Product
- SKU:
- 16-16-120102
- Additional Names:
- ApoAII|In Vitro Diagnostic, Cardiovascular Research
- Buffer:
- Frozen in 10 mM NH4HCO3, pH 7.4
- CE/IVD:
- RUO
- Extra Details:
- Apolipoprotein A-II (ApoA-II), constituting 25% of HDL-associated apolipoproteins, circulates in plasma at 30-50 mg/100 mL. This 17.4 kDa protein stabilizes HDL structure and modulates lipid metabolism, though its physiological role remains debated. ApoA-II inhibits lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP), influencing HDL remodeling and cholesterol efflux. While some studies suggest proatherogenic effects via reduced HDL antioxidant capacity, large prospective cohorts demonstrate an inverse correlation between ApoA-II levels and coronary artery disease (CAD) risk, independent of HDL cholesterol. Alcohol consumption increases ApoA-II production, correlating with elevated HDL-C and potential cardioprotection. Genetic variants like APOA2 rs5082 interact with saturated fat intake, modulating obesity and type 2 diabetes risk. Clinically, ApoA-II deficiency shows minimal lipid disruption, whereas elevated levels associate with hypertriglyceridemia, insulin resistance, and pancreatic cancer biomarker potential. Emerging therapies target ApoA-II's role in amyloidosis inhibition and HDL particle engineering for atherosclerosis management. Despite conflicting mechanistic insights, ApoA-II remains a critical player in HDL dynamics and metabolic disease pathways.
- Formulation:
- Frozen in 10 mM NH4HCO3, pH 7.4
- Molecular Weight:
- 17,400 Da
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
