Kallikrein, Rat
Product Sizes
0.05 mg
16-16-110112-RAT-0.05MG
About this Product
- SKU:
- 16-16-110112-RAT
- Additional Names:
- Inhibitor Assay, Rheumatoid Arthritis, Complement System, Diabetes, Hereditary Angioedema , Coagulation|KK, KLKB1, Kininogenase, Kininogenin, Fletcher factor, KLK3
- Application:
- Block/Inhibit/Neutralise
- Buffer:
- Frozen in 11.9 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4
- CE/IVD:
- RUO
- Extra Details:
- Kallikrein is a family of secreted serine proteases with diverse physiological roles, most notably in the generation of bradykinin, a potent vasodilator involved in regulating blood pressure, inflammation, and pain. In plasma, kallikrein exists as an inactive precursor called prekallikrein, which is synthesized in the liver and activated by factor XII during the intrinsic coagulation pathway. Upon activation, kallikrein cleaves kininogen to release bradykinin, thereby increasing vascular permeability and contributing to inflammatory responses. Structurally, kallikreins share a conserved catalytic triad essential for their proteolytic activity and are stabilized by multiple disulfide bridges. Clinically, dysregulation of kallikrein activity is implicated in hereditary angioedema (HAE), a rare genetic disorder characterized by episodes of severe swelling due to excessive bradykinin production. Kallikrein inhibitors are used therapeutically to manage HAE by blocking bradykinin release and preventing angioedema attacks. Additionally, kallikreins play roles in blood clotting, skin desquamation, and are being studied for their involvement in cancer, kidney function, and other inflammatory diseases.
- Formulation:
- Frozen in 11.9 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4
- Molecular Weight:
- 87,000 KDa
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Prepared from Sprague-Dawley Rat Plasma taken from healthy animals with no signs of quarantinable or exotic disease housed at a USDA-licensed facility. Country of Origin: Rat plasma was obtained from healthy animals of US origin and under the care of a registered veterinarian.
- Storage Conditions:
- -70[o]C
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
