IgM mu chain
Product Sizes
1 mg
16-16-090713-MU-1MG
5 mg
16-16-090713-MU-5MG
About this Product
- SKU:
- 16-16-090713-MU
- Additional Names:
- IgM mu chain|Structural Studies, Antisera Production, Immunodeficiency, Waldenstroem's macroglobulinemia
- Buffer:
- Lyophilized from 1.0 M acetic acid. Reconstitute with 1.0 M acetic acid to the pre-lyophilization volume. Dilutions must be made in Acetic Acid.
- CE/IVD:
- RUO
- Extra Details:
- The IgM heavy chain, known as the mu (u) chain, is a fundamental component of IgM antibodies and consists of 576 amino acids. Each IgM molecule is composed of five mu chains, forming a pentameric structure that enables robust antigen binding and efficient activation of the complement system. The mu chain is distinguished by its high degree of evolutionary conservation across species, more so than the heavy chains of IgG or IgA, underscoring its essential role in the immune response. Purification of the mu chain is typically achieved by reducing the disulfide bonds that link it to the kappa and lambda light chains, allowing for detailed structural and functional studies. Clinically, abnormalities in the mu chain can be associated with immunodeficiency disorders, such as selective IgM deficiency, and certain B-cell malignancies like Waldenstroem's macroglobulinemia. Additionally, the mu chain serves as a target in diagnostic assays for early infection and is a key marker in the study of B-cell development and immune system evolution.
- Formulation:
- Lyophilized from 1.0 M acetic acid. Reconstitute with 1.0 M acetic acid to the pre-lyophilization volume. Dilutions must be made in Acetic Acid.
- Molecular Weight:
- 75,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Antibody: Isotype Controls
