IgM Fc5mu
Product Sizes
1 mg
16-16-090713-MFC5U-1MG
5 mg
16-16-090713-MFC5U-5MG
About this Product
- SKU:
- 16-16-090713-MFC5U
- Additional Names:
- IgM Fc5u, IgM FC5mu, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable.|Structural Studies, Antisera Production
- Buffer:
- Frozen in PBS, pH 7.4
- CE/IVD:
- RUO
- Extra Details:
- The Immunoglobulin M (IgM) Fc5u fragment, comprising the constant region (Cu2-Cu4 domains) of the u heavy chain, mediates critical immune functions despite lacking antigen-binding capacity. This fragment drives complement fixation via C1q binding, with studies showing its pentameric form in Waldenstroem macroglobulinemia exhibits 19-fold higher complement activation than intact IgM. Structurally, the Fc5u's conserved N-glycosylation at Asn-297 stabilizes its conformation and enables interactions with Fc receptors (FcuR) on B cells, T cells, and NK cells, modulating immune responses like phagocytosis and antibody-dependent cytotoxicity. While IgM typically lacks placental transfer due to its size, Fc5u's interaction with FcRn-a receptor critical for IgG transcytosis-hints at nuanced roles in maternal-fetal immunity, though this requires further elucidation.
- Formulation:
- Frozen in PBS, pH 7.4
- Molecular Weight:
- 342 Kda
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Antibody: Isotype Controls
