Immunoglobulin G, Rat
Product Sizes
10 mg
16-16-090707-RAT-10MG
About this Product
- SKU:
- 16-16-090707-RAT
- Additional Names:
- ELISA, In Vitro Diagnostic, Proteomics, Biotherapeutics|IgG, Immunoglobulin Gamma
- Application:
- ELISA
- Buffer:
- Lyophilized in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3
- CE/IVD:
- RUO
- Extra Details:
- Immunoglobulin G (IgG), the most abundant plasma antibody (8-18 mg/mL), comprises four subclasses (IgG1-4) with distinct effector functions mediated by structural variations in their Fc regions. IgG neutralizes pathogens through Fab-mediated antigen binding and Fc-dependent mechanisms, including complement activation (via C1q binding to IgG1/IgG3) and antibody-dependent cellular cytotoxicity (ADCC) through FcG GammaRIIIa engagement on natural killer cells. IgG's extended half-life (21 days) arises from pH-dependent FcRn recycling, which also facilitates placental transfer, conferring neonatal immunity. Clinically, IgG deficiencies manifest as recurrent sinopulmonary infections: selective IgG subclass deficiencies (e.g., IgG2 impairing antipolysaccharide responses), while agammaglobulinemia features near-absent IgG (<200 mg/dL). Autoimmune disorders exhibit subclass-specific involvement-IgG4 drives MuSK myasthenia gravis through functional blockade, whereas IgG1/IgG3 mediate tissue damage in pemphigus via complement activation. Therapeutically, intravenous IgG (IVIG) at 2 g/kg modulates immunity in Guillain-Barre syndrome by Fc receptor saturation and anti-idiotypic effects. Diagnostic applications leverage IgG's specificity in serological assays, with subclass profiling guiding immunodeficiency management.
- Formulation:
- Lyophilized in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3
- Molecular Weight:
- 150 Kda
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Rat serum was obtained from healthy animals of US origin.
- Storage Conditions:
- -20[o]C
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Antibody: Isotype Controls
