Immunoglobulin G Fab Fragment (IgG Fab)
Product Sizes
1 mg
16-16-090707-FAB-1MG
5 mg
16-16-090707-FAB-5MG
10 mg
16-16-090707-FAB-10MG
About this Product
- SKU:
- 16-16-090707-FAB
- Additional Names:
- Biotherapeutics, Flow Cytometry, Immunohistochemistry, Antisera Production|IgG Fab
- Application:
- Flow Cytometry, Immunohistochemistry
- Buffer:
- Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.
- CE/IVD:
- RUO
- Extra Details:
- The IgG Fab (Fragment antigen-binding) fragment is a monovalent proteolytic product of Immunoglobulin G. Each Fab fragment retains the variable domains (VH and VL) responsible for antigen specificity while lacking the Fc-mediated effector functions, enabling targeted antigen neutralization without immune activation. This structural configuration prevents cross-linking-induced precipitation or cellular "patching/capping," making Fab fragments ideal for precise antigen targeting in solution or on cell surfaces. Diagnostically, Fab fragments enable multiplex immunoassays by preventing Fc-mediated cross-reactivity, facilitating simultaneous detection of multiple antigens in flow cytometry and immunohistochemistry. Their monovalent nature ensures minimal background noise in assays requiring high specificity. Emerging applications include autoimmune disease management, where Fab fragments neutralize autoantibodies while circumventing complement activation. By combining targeted binding with reduced immunogenicity, IgG Fab fragments represent a versatile tool in both clinical and research settings.
- Formulation:
- Frozen in 20 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.
- Molecular Weight:
- 50,000 Da
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Antibody: Isotype Controls
