Immunoglobulin G1 FC (IgG1-M-FC)
Product Sizes
1 mg
16-16-090707-1M-FC-1MG
About this Product
- SKU:
- 16-16-090707-1M-FC
- Additional Names:
- Flow Cytometry, ELISA, Antisera Production, In Vitro Diagnostics, Proteomics|IgG FC, Fc stands for "Fragment Constant region" or "Fragment Crystallizable region." The names are essentially interchangable.
- Application:
- ELISA, Flow Cytometry
- Buffer:
- Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3.
- CE/IVD:
- RUO
- Extra Details:
- The Fc (fragment crystallizable) region of immunoglobulin G, while not binding antigen, contains crucial biological activities and antigenic determinants. This homodimeric glycoprotein comprises CH2 and CH3 domains and mediates immune effector functions through interactions with Fc receptors, C1q, and FcRn. Fc fragments orchestrate antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and phagocytosis while controlling IgG's serum half-life via pH-dependent FcRn binding. The conserved N-linked glycosylation at Asn-297 is essential for structural stability and receptor interactions. Altered Fc glycosylation patterns correlate with autoimmune conditions including rheumatoid arthritis, where reduced galactosylation and sialylation indicate inflammatory disease states. Fc receptor polymorphisms are also associated with autoimmune disease development.
- Formulation:
- Frozen in 50 mM Tris-HCl, pH 8.0, with 200 mM NaCl and 0.05% NaN3.
- Molecular Weight:
- 50,000 Da
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human myeloma plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Antibody: Isotype Controls
