Haptoglobin, Phenotype 2-2
Product Sizes
1 mg
16-16-080116-2-2-1MG
5 mg
16-16-080116-2-2-5MG
About this Product
- SKU:
- 16-16-080116-2-2
- Additional Names:
- ELISA, Protein Chemistry, Inflammation, Sickle Cell Anemia, Glycosylation, Stroke, Central Nervous System Injury, Diabetes, Cardiovascular Disease, In Vitro Diagnostic, Iron Metabolism, Cancer|Zonulin, HPT, HP, BP, HP2ALPHA2, HPA1S
- Application:
- ELISA
- Buffer:
- Salt-free lyophilized solid.
- CAS Number:
- 9087-69-8
- CE/IVD:
- RUO
- Extra Details:
- Haptoglobin 2-2 (Hp2-2) is a homozygous phenotype of the haptoglobin protein, characterized by cyclic polymer structures formed by the Hp2 allele. Functionally, Hp2-2 exhibits reduced antioxidant capacity compared to Hp1-1 and Hp2-1 phenotypes due to inferior hemoglobin-binding affinity and impaired clearance of hemoglobin-haptoglobin complexes via CD163 receptors. This diminished efficacy in neutralizing free hemoglobin's oxidative effects predisposes Hp2-2 carriers to multiple pathologies. Clinically, Hp2-2 is strongly associated with accelerated atherosclerosis in diabetic patients, evidenced by increased carotid intima-media thickness and oxidative stress markers. It also elevates risks for chronic kidney disease progression and end-stage renal disease, with a 3.84-fold increased hazard ratio for mortality in South Indian populations. Additionally, Hp2-2 correlates with familial epilepsy through hypohaptoglobinemia-mediated delayed hemoglobin clearance in neural tissues. Diagnostic applications include Hp phenotyping to stratify cardiovascular risk in diabetes, guiding targeted interventions like vitamin E supplementation. The phenotype's association with hypertension and overweight status further underscores its clinical relevance in metabolic disorders.
- Formulation:
- Salt-free lyophilized solid.
- Molecular Weight:
- 400,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
