Haptoglobin, Phenotype 1-1
Product Sizes
1 mg
16-16-080116-1-1-1MG
5 mg
16-16-080116-1-1-5MG
About this Product
- SKU:
- 16-16-080116-1-1
- Additional Names:
- ELISA, Protein Chemistry, Inflammation, Sickle Cell Anemia, Glycosylation, Stroke, Central Nervous System Injury, Diabetes, Cardiovascular Disease, In Vitro Diagnostic, Iron Metabolism, Cancer|Zonulin, HPT, HP, BP, HP2ALPHA2, HPA1S
- Application:
- ELISA
- Buffer:
- Salt-free lyophilized solid.
- CAS Number:
- 9087-69-8
- CE/IVD:
- RUO
- Extra Details:
- Human haptoglobin 1-1 (Hp1-1), the most efficient phenotype of the hemoglobin-binding glycoprotein, forms dimers through A Alpha1B Beta-chain associations, enabling rapid neutralization of toxic free hemoglobin (Hb) with a binding capacity of 1.25-1.5 mg Hb per mg Hp. Its superior antioxidant capacity stems from compact polymer structures that enhance CD163 receptor-mediated clearance of Hb-Hp complexes by macrophages, suppressing iron-driven oxidative stress and NF-K KappaB inflammatory pathways more effectively than Hp2-1 or Hp2-2 phenotypes. Clinically, Hp1-1 demonstrates protective effects against diabetic vascular complications by preserving endothelial nitric oxide bioavailability and reducing advanced glycation end-product formation, lowering retinopathy and nephropathy risks by 50-70% compared to other phenotypes. In sickle cell disease, Hp1-1 carriers exhibit 40% lower cell-free Hb levels during crises and a twofold reduction in multiorgan failure risk due to enhanced Hb sequestration. Paradoxically, Hp1-1 prevalence increases in cirrhosis (55% vs. 30% in healthy populations) as hepatic synthesis shifts toward acute-phase production despite systemic oxidative stress.
- Formulation:
- Salt-free lyophilized solid.
- Molecular Weight:
- 86,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
