Complement C5
Product Sizes
0.05 mg
16-16-030305-0.05MG
0.25 mg
16-16-030305-0.25MG
About this Product
- SKU:
- 16-16-030305
- Additional Names:
- C5|Inflammation, Infection, Autoimmune Diseases, Myasthenia Gravis, Age Related Macular Degeneration
- Buffer:
- Frozen in PBS, pH 7.4
- CAS Number:
- 80295-54-1
- CE/IVD:
- RUO
- Extra Details:
- Complement C5, a glycoprotein composed of A Alpha (115 kDa) and B Beta (75 kDa) chains, serves as the linchpin of complement-mediated immunity. Cleaved by C5 convertases into C5a (potent anaphylatoxin) and C5b (initiator of membrane attack complex/MAC), it bridges inflammatory signaling and pathogen lysis. C5a drives chemotaxis, leukocyte activation, and vascular permeability via C5aR1/C5aR2 receptors, while C5b-9 (MAC) induces microbial cytolysis. C5 deficiency increases susceptibility to recurrent pyogenic infections (e.g., Neisseria) and Leiner's disease. Elevated C5a correlates with rheumatoid arthritis, Guillain-Barre syndrome, and chemotherapy-induced neuropathy.
- Formulation:
- Frozen in PBS, pH 7.4
- Molecular Weight:
- 190,000 Da
- Physical State:
- Frozen
- Purity:
- ≥95% Reacts to C5 antisera on Western Blot
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
