Alpha 2 Antiplasmin
Product Sizes
0.1 mg
16-16-012901-0.1MG
0.5 mg
16-16-012901-0.5MG
1 mg
16-16-012901-1MG
About this Product
- SKU:
- 16-16-012901
- Additional Names:
- A2AP, Alpha-2-plasmin inhibitor (Alpha-2-PI), Serpin F2, AAP, PLI, Alpha-2-AP, A Alpha2AP|Proteolytic Inhibition, Fibrinolysis, Coagulation, In Vitro Diagnostic Testing
- Buffer:
- Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.
- CE/IVD:
- RUO
- Extra Details:
- Alpha-2 antiplasmin (A Alpha2AP) is a key serine protease inhibitor found in plasma at approximately 70 ug/mL, primarily synthesized by the liver. Its main function is to regulate fibrinolysis by rapidly and efficiently inhibiting plasmin, the enzyme responsible for breaking down fibrin clots. By binding to plasmin and preventing its activity, A Alpha2AP stabilizes blood clots and prevents excessive bleeding. It also interferes with plasminogen binding to fibrin and becomes cross-linked to fibrin during clot formation, further enhancing clot stability. Deficiency of A Alpha2AP is a rare inherited coagulation disorder that results in unrestrained plasmin activity and excessive fibrinolysis, leading to a significant risk of spontaneous or postoperative bleeding. This condition may present as severe bleeding episodes, particularly after trauma or surgery. Therapeutically, antifibrinolytic agents such as aminocaproic acid or tranexamic acid are commonly administered to patients with A Alpha2AP deficiency to prevent or control bleeding, especially in surgical settings. Beyond bleeding disorders, elevated A Alpha2AP levels are linked to increased risk and poor outcomes in cardiovascular diseases, including deep vein thrombosis and ischemic stroke, making it a potential therapeutic target in these conditions.
- Formulation:
- Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.
- Molecular Weight:
- 70,000 Da
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
