Alpha 2 Macroglobulin (A2M)
Product Sizes
1 mg
16-16-012013-1MG
5 mg
16-16-012013-5MG
10 mg
16-16-012013-10MG
About this Product
- SKU:
- 16-16-012013
- Additional Names:
- Enzyme Studies, ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Biotherapeutics Studies|A Alpha2-Macroglobulin, Alpha 2 Macroglobulin-Slow Form (Normal/Active), A Alpha2M, A2M, A2MD, CPAMD5, FWP007, S863-7, S-A2M
- Application:
- Control, Detection/Quantitation, ELISA
- Buffer:
- Lyophilized from 30 mM Na Phosphate, pH 7.0 , and 1 mg glycine per 1 mg Alpha 2 Macroglobulin.
- CE/IVD:
- RUO
- Extra Details:
- Alpha-2-macroglobulin (A2M) is a large (725 KDa) plasma glycoprotein found at concentrations of 240 mg/100 ml in men and 290 mg/100 ml in women. This versatile protein functions through a unique "venus-flytrap" mechanism, inhibiting proteases of all catalytic types by forming a tetrameric cage around them. Beyond protease inhibition, A2M binds and transports cytokines, growth factors, zinc, and damaged proteins. It promotes cell migration, enhances immune function by facilitating antigen processing, and stimulates lymphocyte regeneration in irradiated subjects. A2M levels increase in nephrotic syndrome, liver cirrhosis, diabetes, and severe burn. Conversely, levels decrease in acute pancreatitis, hyperfibrinolytic states, and septicemia. Research indicates A2M's involvement in Alzheimer's disease pathology through binding and clearing amyloid-beta peptides. Clinically, A2M shows promise as a therapeutic agent for osteoarthritis, where it inhibits cartilage-degrading enzymes.
- Formulation:
- Lyophilized from 30 mM Na Phosphate, pH 7.0 , and 1 mg glycine per 1 mg Alpha 2 Macroglobulin.
- Molecular Weight:
- 725 Kda
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
