Alpha 2 Macroglobulin (A2M), Fast Form
Product Sizes
0.5 mg
16-16-012013-FF-0.5MG
1 mg
16-16-012013-FF-1MG
5 mg
16-16-012013-FF-5MG
About this Product
- SKU:
- 16-16-012013-FF
- Additional Names:
- Enzyme Studies, ELISA, Antigen for Antibody production, IVD Antigens, Calibrators & Controls, Protein Chemistry Research, Biotherapeutics Studies|A Alpha2-Macroglobulin, F-A Alpha2M, F-A2M, A2MD, CPAMD5, FWP007, S863-7, F-A2M
- Application:
- Control, Detection/Quantitation, ELISA
- Buffer:
- Lyophilized from 100 mM Na Phosphate, pH 7.2
- CE/IVD:
- RUO
- Extra Details:
- Alpha 2 Macroglobulin, Fast Form (F-A2M) arises from structural changes in the Slow Form (S-A2M) after protease entrapment or cleavage of its thiol ester bond. Unlike S-A2M, which inhibits proteases via a "snap-trap" mechanism, F-A2M loses protease-inhibitory capacity and undergoes rapid hepatic clearance (half-life: 2-4 minutes). While F-A2M constitutes only 0.17-0.7% of total plasma A2M in healthy adults, its levels rise in conditions marked by protease activation, such as acute pancreatitis (linked to disease severity), sepsis, and multiple sclerosis. F-A2M serves as a biomarker for protease-driven pathologies, with elevated levels reflecting systemic inflammation or tissue damage. It also shows potential in neurodegenerative diseases, where it may inhibit amyloid fibril formation in Alzheimer's and prion disorders by binding misfolded proteins. Clinically, F-A2M detection aids in monitoring protease activation in sepsis or artificial medical surfaces, while its cytokine-binding properties hint at therapeutic applications for inflammatory conditions.
- Formulation:
- Lyophilized from 100 mM Na Phosphate, pH 7.2
- Molecular Weight:
- 725 Kda
- Physical State:
- Lyophilized
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Source human plasma non-reactive for HBsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
