Defensins, Alpha
Product Sizes
0.1 mg
16-14-081416-0.1MG
1 mg
16-14-081416-1MG
About this Product
- SKU:
- 16-14-081416
- Additional Names:
- Human Neutrophil Peptides, HNP|In Vitro Diagnostic, Antimicrobials, NETosis, Cirrhosis, Autoimmune Disease
- Buffer:
- Frozen in 1 M acetic acid.
- CE/IVD:
- RUO
- Extra Details:
- Alpha-defensins are small (3-4 kDa), cysteine-rich cationic peptides characterized by a conserved triple B Beta-sheet structure stabilized by three disulfide bonds. Primarily secreted by neutrophils and Paneth cells, these peptides exhibit broad-spectrum antimicrobial activity against bacteria, fungi, and enveloped viruses via membrane disruption. Their cationic nature facilitates electrostatic attraction to negatively charged microbial membranes, forming voltage-dependent pores that induce osmotic lysis. Beyond direct pathogen killing, alpha-defensins (e.g., HNP1-3) promote neutrophil extracellular trap (NET) formation and modulate immune responses by enhancing phagocytosis, regulating cytokine production, and suppressing glucocorticoid-mediated immunosuppression. Elevated alpha-defensin levels correlate with alcohol-related liver cirrhosis severity, where they predict hepatic encephalopathy and mortality. In prosthetic joint infections (PJI), synovial alpha-defensin detection via lateral flow assays achieves 92-100% specificity, serving as a rapid diagnostic biomarker. Genetic polymorphisms link alpha-defensin dysregulation to autoimmune disorders like lupus and neuropsychiatric conditions such as schizophrenia. Conversely, deficiencies increase susceptibility to pyogenic infections, particularly in immunocompromised individuals.
- Formulation:
- Frozen in 1 M acetic acid.
- Molecular Weight:
- <3,500 Da
- Physical State:
- Frozen
- Purity:
- ≥95%
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Neutrophils shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
