Cathepsin L
Product Sizes
0.025 mg
16-12-030112-0.025MG
0.1 mg
16-12-030112-0.1MG
1 mg
16-12-030112-1MG
About this Product
- SKU:
- 16-12-030112
- Additional Names:
- Cancer, SARS-CoV-2, Emphysema, Atherosclerosis, In Vitro Diagnostic|CatL, Major excreted protein (MEP), CTSL
- Buffer:
- Frozen in 20 mM Malonate, pH 5.5, 1 mM EDTA, 400 mM NaCl.
- CAS Number:
- 60616-82-2
- CE/IVD:
- RUO
- Extra Details:
- Cathepsin L (CTSL) is one of the most potent lysosomal cysteine endopeptidases, demonstrating significantly higher specific activity than cathepsins B and H in degrading physiological protein substrates. As a member of the papain-like protease family, CTSL plays crucial roles in protein catabolism, antigen processing, bone resorption, and ovulation. CTSL is widely expressed in eukaryotic cells, functioning primarily within lysosomes but also secreted extracellularly. It efficiently degrades various substrates including extracellular matrix proteins (laminins, fibronectin, collagens), cytoplasmic, and nuclear proteins. CTSL exhibits specificity for aromatic residues in the P2 position with limited prime-site selectivity4. CTSL is significantly upregulated in multiple cancer types, particularly breast cancer, where it serves as a powerful predictor of relapse and survival following treatment. Its ability to degrade extracellular matrix facilitates tumor invasion and metastasis. CTSL plays key roles in, coronary heart disease progression SARS-CoV-2 infection, and pulmonary emphysema development. CTSL represents a promising therapeutic target, with inhibitors showing potential in preventing cancer metastasis, treating COVID-19 by blocking viral entry mechanisms, and managing atherosclerosis progression
- Formulation:
- Frozen in 20 mM Malonate, pH 5.5, 1 mM EDTA, 400 mM NaCl.
- Molecular Weight:
- 25,000 - 29,000 Da
- Physical State:
- Frozen
- Purity:
- Not Listed
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Dry Ice
- Source:
- Prepared from liver shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
