Lipoproteins, Low Density, Tissue Culture Grade (LDL-TC)
Product Sizes
1 mg
12-16-120412-TC-1MG
5 mg
12-16-120412-TC-5MG
10 mg
12-16-120412-TC-10MG
About this Product
- SKU:
- 12-16-120412-TC
- Additional Names:
- Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease|LDL-TC, LDL-LEL, B Beta-Lipoprotein, LDL, Low density lipoprotein
- Application:
- Tissue Culture
- Buffer:
- Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA
- CE/IVD:
- RUO
- Extra Details:
- Low-density lipoprotein (LDL) is a major plasma lipoprotein, with normal fasting concentrations ranging from 2.0 to 3.5 g/L, and accounts for about 50% of the total lipoprotein mass in the bloodstream. LDL's primary role is to transport cholesterol and cholesteryl esters from the liver to peripheral tissues, where cholesterol is essential for membrane structure and steroid hormone synthesis. The protein component, apolipoprotein B-100, enables LDL to bind to LDL receptors on cell surfaces, facilitating cholesterol uptake via receptor-mediated endocytosis. Elevated LDL levels are a well-established risk factor for atherosclerosis and coronary heart disease, as excess LDL cholesterol can accumulate in arterial walls, triggering inflammation and plaque formation. LDL is also implicated in other conditions such as stroke and peripheral artery disease. Clinically, LDL measurement is central to cardiovascular risk assessment and guides therapeutic interventions. In research, LDL is used to study lipid metabolism, receptor interactions, and the development of lipid-lowering drugs.
- Formulation:
- Liquid in 150 mM NaCl, pH 7.4, and 0.01% EDTA
- Molecular Weight:
- 2,300,000 Da
- Physical State:
- Liquid
- Purity:
- single arc by IEP against antisera to whole human serum. Essentially free of other plasma lipoproteins and chylomicrons as determined by electrophoresis using a SPIFE Vis Cholesterol gel kit for lipid
- Purification:
- Liquid Chromatography Methods
- Shipping Conditions:
- Blue Ice
- Source:
- Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- Athens Research & Technology Inc.
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Native
