SPR-450
Alpha Synuclein Filaments
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPR-450
- Zusätzliche Namen:
- Alpha-synuclein filaments, Alpha-synuclein aggregates, Alpha-synuclein PFF, Alpha-synuclein PFFs, Alpha-synuclein seed, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, PARK1, SYN, Parkinson's disease familial 1 Protein, Alpha-synuclein protofibrils, Alpha-synuclein proto-fibrils, Asyn
- Anwendung:
- SDS-PAGE, WB, FuncS
- Konzentration:
- 2 mg/ml
- Molekulargewicht:
- ~14.46 kDa
- Reinheit:
- >95%
- Aufreinigung:
- Ion Exchange
- Lagerbedingungen:
- -70[o]C
- Hersteller:
- StressMarq Biosciences
- ABP:
- No Import Docs
- Buffer:
- PBS
- Immunogen:
- Alpha Synuclein Filaments
- Spezies:
- Human
- Uniprot:
- P37840
- Synonyme:
- alpha-synuclein;I+/--synuclein;NACP;non A-beta component of AD amyloid;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;PARK1;PARK4;PD1;synuclein alpha-140;synuclein, alpha (non A4 component of amyloid precursor);truncated alpha synuclein
- Weitere Details:
- Alpha-synuclein filaments are hallmark pathological structures in neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. These insoluble fibrillar aggregates arise from the misfolding and self-assembly of alpha-synuclein, a presynaptic neuronal protein encoded by the SNCA gene. Under pathological conditions, native alpha-synuclein undergoes conformational changes that promote B Beta-sheet-rich filament formation. These filaments accumulate in neuronal and glial cells, disrupting essential cellular functions including proteostasis, mitochondrial dynamics, and synaptic signaling. Their presence correlates with progressive neurodegeneration and clinical decline. Recent advances in cryo-electron microscopy have revealed distinct filament structures associated with different synucleinopathies, suggesting disease-specific conformers with prion-like properties. These filaments can seed the misfolding of native alpha-synuclein, facilitating the spread of pathology across brain regions. Alpha-synuclein filaments are also being explored as biomarkers for early diagnosis and disease staging. Their unique biochemical signatures and spatial distribution offer promising avenues for targeted imaging and therapeutic intervention. Strategies aimed at inhibiting filament formation, promoting clearance, or stabilizing native alpha-synuclein are under active investigation. In summary, alpha-synuclein filaments are not only structural indicators of disease but also active drivers of neurodegeneration. Understanding their formation, propagation, and cellular impact is essential for developing precision therapies and improving outcomes for patients with synucleinopathies.
- Versandbedingungen:
- Dry Ice