SPC-939
CDK10 Antibody (pThr196)
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPC-939
- Zusätzliche Namen:
- CDK10, Cyclin-dependent kinase 10, Cell division protein kinase 10, CDC2-related protein kinase, CDK10_HUMAN, PISSLRE, Serine/threonine protein kinase PISSLRE
- Anwendung:
- WB, Microarray
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Rabbit
- Reaktivitäten:
- Human
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.025% Thimerosal
- Immunogen:
- A phospho-specific peptide corresponding to residues surrounding Thr196 of human CDK10 (AA193-199)
- Uniprot:
- Q15131
- Synonyme:
- ALSAS;CDC2-related protein kinase;cell division protein kinase 10;cyclin-dependent kinase (CDC2-like) 10;cyclin-dependent kinase 10;cyclin-dependent kinase related protein;PISSLRE;serine/threonine protein kinase PISSLRE;Serine/threonine-protein kinase PISSLRE
- Weitere Details:
- CDK10 is a serine/threonine kinase involved in regulating the G2-M phase of the cell cycle. Although historically studied in the context of cellular proliferation, recent evidence suggests CDK10 may also influence neuronal differentiation, cytoskeletal dynamics, and transcriptional regulation. Phosphorylation at threonine 196 (pThr196) is critical for CDK10 activation and function. In neurons, dysregulation of CDK10 activity may disrupt cell cycle re-entry, a pathological hallmark observed in several neurodegenerative diseases, including Alzheimer's disease. As a modulator of both cell cycle and transcriptional machinery, CDK10 represents a novel candidate for investigating the molecular underpinnings of neurodegeneration.
- Versandbedingungen:
- Blue Ice