SPC-785
LRP1 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPC-785
- Zusätzliche Namen:
- LRP1, LRP-1, LRP-85, LRP-515, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1, CD91, LRPICD, APOER, APR
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH 7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Synthetic peptide from the N-terminal of Human Low-density lipoprotein receptor-related protein 1 (aa. 160-260)
- Uniprot:
- Q07954
- Synonyme:
- A2MR;alpha-2-macroglobulin receptor;APOER;apolipoprotein E receptor;APR;CD91;IGFBP-3R;IGFBP3R;IGFBP3R1;KPA;low density lipoprotein receptor-related protein 1;LRP;LRP1A;prolow-density lipoprotein receptor-related protein 1;TbetaR-V/LRP-1/IGFBP-3 receptor;TGFBR5;type V tgf-beta receptor
- Weitere Details:
- LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a multifunctional endocytic receptor involved in lipid metabolism, protease clearance, and cell signaling. In the brain, LRP1 regulates amyloid-beta clearance, synaptic plasticity, and blood-brain barrier integrity. Dysregulation of LRP1 is associated with Alzheimer's disease, where impaired AB Beta clearance contributes to plaque accumulation and neurotoxicity. LRP1 also modulates neuroinflammatory responses and interacts with key signaling pathways, including Wnt and TGF-B Beta. Its broad functional repertoire and role in maintaining neural homeostasis make LRP1 a critical target in neurodegenerative disease research and therapeutic development.
- Versandbedingungen:
- Blue Ice