SPC-400
NHE3 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPC-400
- Zusätzliche Namen:
- Sodium / Hydrogen Exchanger 3, SLC9A3, Na+/H+ exchanger 3, isoform 3, Solute carrier family 9 member 3, NHE3MGC126720, MGC126718, solute carrier family 9 (sodium/hydrogen exchanger) member 3, NHE-3, Na(+)/H(+) exchanger 3, Sodium/hydrogen exchanger 3
- Anwendung:
- IHC, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Rat
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Rabbit
- Reaktivitäten:
- Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Synthetic peptide mapping to AA 809 to 831 of rat sequence
- Uniprot:
- P26433
- Synonyme:
- Na(+)/H(+) exchanger 3;NHE-3;Nhe3;plasma membrane ion transport protein;sodium/hydrogen exchanger 3;Solute carrier family 9 (sodium/hydrogen exchanger 3), antiporter 3, Na+/H+ (amiloride insensitive);solute carrier family 9 (sodium/hydrogen exchanger), member 3;solute carrier family 9 member 3;solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
- Weitere Details:
- Sodium-hydrogen exchanger 3 (NHE3), encoded by SLC9A3, is a membrane-bound transporter that mediates the electroneutral exchange of intracellular H+ for extracellular Na+. While primarily studied in renal and intestinal physiology, emerging evidence suggests NHE3 may influence neurodegenerative processes through its role in pH regulation, ion homeostasis, and cellular signaling. NHE3 is regulated by phosphorylation via kinases such as PKA, SGK1, and CK2, and its dysregulation may contribute to altered neuronal excitability and glial function. Aberrant NHE3 activity could exacerbate neuroinflammation and oxidative stress, both of which are implicated in Alzheimer's disease and other neurodegenerative disorders. Understanding NHE3's role in the brain may reveal novel therapeutic targets for modulating ionic balance and neuroinflammatory responses in neurodegeneration.
- Versandbedingungen:
- Blue Ice