SPC-211
HO-1 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPC-211
- Zusätzliche Namen:
- HSP32, HMOX1, Heme oxygenase 1, HO, HO1, 32 kD, bK286B10, D8Wsu38e, heat shock protein 32 kD, heat shock protein 32kD, Heat shock protein, Heme oxygenase (decycling) 1, Hemox, HMOX 1, Hmox, Hmox1, HMOX1_HUMAN, HO 1, HO-1, Heme Oxygenase-1, Haem Oxygenase-1, Heat Shock Protein 32, Heme Oxygenase (Decyclizing), EC 1.14.14.18
- Anwendung:
- IHC, WB, IP
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Rat
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Rat native full-length HO-1 purified from liver tissue
- Uniprot:
- P06762
- Synonyme:
- heme oxygenase (decycling) 1;heme oxygenase (decyclizing) 1;heme oxygenase 1;Heox;HEOXG;Hmox;Ho-1;Ho1;hsp32
- Weitere Details:
- Heme oxygenase-1 (HO-1), also known as heat shock protein 32, is an inducible enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide-each with distinct biological functions. Biliverdin is rapidly converted to bilirubin, a potent antioxidant, while carbon monoxide acts as a signaling molecule with anti-inflammatory and vasodilatory properties. Free iron, although potentially toxic, is sequestered by ferritin to limit oxidative damage. HO-1 is strongly upregulated in response to oxidative stress, inflammation, and neurotoxic insults, positioning it as a key cytoprotective factor in the central nervous system. Its expression is elevated in various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it helps mitigate neuronal injury by reducing reactive oxygen species and modulating immune responses. Unlike its constitutive isoform HO-2, HO-1 is dynamically regulated and serves as a frontline defense against cellular stress. Deficiency in HO-1 has been linked to increased neuroinflammation, impaired stress tolerance, and heightened vulnerability to neurodegenerative pathology. Given its dual role in detoxifying free heme and generating neuroprotective metabolites, HO-1 is a promising therapeutic target for modulating oxidative stress and inflammation in neurodegenerative disease research.
- Versandbedingungen:
- Blue Ice