SPC-168
Rab5 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPC-168
- Zusätzliche Namen:
- Rab 5A, RAS associated protein RAB5A, Ras related protein Rab 5 A
- Anwendung:
- IHC, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Rabbit
- Reaktivitäten:
- Bovine, Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Human Rab5 synthetic peptide conjugated to KLH; identical to dog Rab5 sequence over the residues
- Uniprot:
- P20339
- Synonyme:
- RAB5;RAS-associated protein RAB5A;ras-related protein Rab-5A
- Weitere Details:
- Rab5 is a 24 kDa GTPase that regulates early endosome dynamics and endocytic trafficking. It is ubiquitously expressed and localizes to early endosomes and the plasma membrane. Rab5 controls the fusion of endocytic vesicles with early endosomes and mediates homotypic endosome fusion. It recruits effectors such as EEA1 and Rabaptin-5 to facilitate vesicle docking and fusion. In the nervous system, Rab5 is essential for receptor internalization, synaptic vesicle recycling, and neurotrophin signaling. Dysregulation of Rab5 activity can lead to endosomal dysfunction, impaired signaling, and neurodegeneration. It is widely used as a marker of early endosomes and is a key player in maintaining neuronal homeostasis.
- Versandbedingungen:
- Blue Ice