SPC-120
Erk1/2 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SPC-120
- Zusätzliche Namen:
- ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3
- Anwendung:
- Flow Cytometry, IHC, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Rat
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Rabbit
- Reaktivitäten:
- Bovine, Human, Mouse, Rat, Ovine, Insect/Arthropod
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH.
- Uniprot:
- P21708
- Synonyme:
- Erk-1;ERK1;ERT2;Esrk1;extracellular signal-regulated kinase 1;insulin-stimulated MAP2 kinase;MAP kinase 1;MAP kinase 3;MAP kinase isoform p44;MAPK 1;MAPK 3;MAPK1;microtubule-associated protein 2 kinase;mitogen-activated 3;mitogen-activated protein kinase 1;mitogen-activated protein kinase 3;MNK1;p44;p44-ERK1;p44erk1;p44mapk;Prkm3
- Weitere Details:
- Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation-hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research. As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression.
- Versandbedingungen:
- Blue Ice