SMC-616
PPM1H Antibody, Clone 10D2
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SMC-616
- Zusätzliche Namen:
- Protein phosphatase Mg2+/Mn2+ dependent 1H, NERPP2C, Protein phosphatase 1H, PPM1H, KIAA1157
- Anwendung:
- WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Recombinant Human PPM1H Protein
- Klon:
- 10D2
- Uniprot:
- Q9ULR3
- Synonyme:
- ARHCL1;NERPP-2C;neurite extension-related protein phosphatase related to PP2C;protein phosphatase 1H;protein phosphatase 1H (PP2C domain containing);ras homolog gene family, member C like 1;URCC2
- Weitere Details:
- PPM1H (Protein Phosphatase, Mg2+/Mn2+ Dependent 1H) is a serine/threonine phosphatase that modulates key signaling pathways in cellular homeostasis. It acts as a negative regulator of LRRK2 signaling by dephosphorylating Rab GTPases, which are critical for vesicle trafficking and lysosomal function. PPM1H has been identified as a gatekeeper of bone morphogenetic protein (BMP) signaling, preventing excessive activation through targeted dephosphorylation. It also serves as an independent prognostic biomarker in non-small cell lung cancer. In neuroscience, PPM1H's regulation of Rab proteins and BMP pathways positions it as a potential modulator of neuroinflammation and synaptic integrity. Its role in maintaining vesicular transport and signaling balance makes it a candidate for therapeutic exploration in neurodegenerative diseases such as Parkinson's.
- Versandbedingungen:
- Blue Ice