SMC-469D-APC
Neuroligin-4 Antibody, Clone N98/7 : APC
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SMC-469D-APC
- Zusätzliche Namen:
- ASPGX2, AUTSX2, HLNX, HNLX, KIAA1260, MGC22376, NLGN, NLGN4, NLGN4X, neuroligin-4 X-linked, neuroligin X, neuroligin 4, X-linked
- Anwendung:
- IHC, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Mouse
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- See Manual
- Hersteller:
- StressMarq Biosciences
- Host:
- Mouse
- Reaktivitäten:
- Mouse, Rat
- Buffer:
- 95.46mM Phosphate, 2.48mM MES and 2mM EDTA
- Immunogen:
- Fusion protein amino acids 782-945 (intracellular C-terminus) of mouse Neuroligin 4. ~45% identity with Neuroligin-1, -2 and -3.
- Klon:
- N98/7 (Formerly sold as S98-7)
- Uniprot:
- B0F2B4
- Synonyme:
- N;neural cell adhesion protein neuroligin 4;neuroligin 4-like;neuroligin 4, X-linked;Neuroligin-4;neurologin-4;Nl;NL-4;NL4;Nlgn4;Nlgn4x
- Weitere Details:
- Neuroligin 4 (NLGN4) is a neuronal cell surface protein that contributes to the formation and remodeling of synapses in the central nervous system. As a member of the neuroligin family, NLGN4 binds to presynaptic neurexins, facilitating the development of functional synaptic junctions. NLGN4 is implicated in the specification of inhibitory synapses and is enriched in postsynaptic densities. It interacts with scaffolding proteins such as DLG4 (PSD-95), influencing synaptic stability and receptor clustering. Mutations in NLGN4 have been linked to autism spectrum disorders and intellectual disability, highlighting its role in neurodevelopmental processes. In neurodegenerative disease, synaptic dysfunction is a key early event. Altered NLGN4 expression or function may disrupt inhibitory signaling, contributing to excitotoxicity and network imbalance. Its involvement in synaptic maintenance suggests that NLGN4 may serve as a biomarker for early synaptic pathology and a potential target for therapeutic intervention. Understanding NLGN4's role in synaptic regulation offers valuable insights into the molecular basis of cognitive decline and neurodegeneration.
- Versandbedingungen:
- Blue Ice