SMC-450
PINK1 Antibody, Clone N4/15
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SMC-450
- Zusätzliche Namen:
- Parkinson disease (autosomal recessive) 6, EC 2.7.11.1, PARK6, serine/threonine-protein kinase PINK1 mitochondrial, PTEN-induced putative kinase protein 1, protein kinase BRPK, BRPK, FLJ27236, PTEN induced putative kinase 1, Phosphatase and Tensin Homolog
- Anwendung:
- IHC, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse, Rat
- ABP:
- No Import Docs
- Buffer:
- PBS pH7.4, 50% glycerol, 0.1% sodium azide
- Immunogen:
- Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1. 82% identical to rat and 81% identical to mouse. >30% identity with DMPK.
- Klon:
- N4/15 (Formerly sold as S4-15)
- Uniprot:
- Q9BXM7.1
- Synonyme:
- BRPK;PARK6;protein kinase BRPK;PTEN induced putative kinase 1;PTEN-induced putative kinase protein 1;serine/threonine-protein kinase PINK1, mitochondrial
- Weitere Details:
- PINK1 (PTEN-induced putative kinase 1) is a mitochondrial serine/threonine kinase that safeguards mitochondrial integrity and function. It plays a central role in mitophagy-the selective autophagic clearance of damaged mitochondria-by phosphorylating mitochondrial substrates and recruiting the cytosolic E3 ubiquitin ligase Parkin to the outer mitochondrial membrane (OMM). PINK1 is synthesized as a 63 kDa precursor and undergoes proteolytic processing to generate cleaved forms that localize to various sub-mitochondrial compartments. Its kinase domain faces the cytosol, enabling interactions with cytosolic proteins involved in mitochondrial quality control. Mutations in PINK1 are linked to autosomal recessive early-onset Parkinson's disease and are associated with mitochondrial dysfunction, alpha-synuclein aggregation, and impaired proteasome activity. Loss of PINK1 function disrupts mitochondrial dynamics and neuronal survival, making it a key target in neurodegenerative disease research.
- Versandbedingungen:
- Blue Ice