SMC-323
Slo2.2 Antibody, Clone N3/26
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SMC-323
- Zusätzliche Namen:
- KCNT1, potassium channel subfamily T member 1, bA100C15.2, SLACK, KCa4.1, KIAA1422, FLJ41282
- Anwendung:
- IHC, WB, IF, ICC, Microarray
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Rat
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Fusion protein amino acids 1168-1237 of rat Slo2.2 (Slack)
- Klon:
- N3/26 (Formerly sold as S3-26)
- Uniprot:
- Q9Z258
- Synonyme:
- potassium channel subfamily T member 1;potassium channel subunit (Slack);potassium channel, sodium-activated subfamily T, member 1;potassium channel, subfamily T, member 1;rSlo2;sequence like a calcium-activated potassium channel subunit;Slack
- Weitere Details:
- Slo2.2, a member of the Slo potassium channel family, is a sodium-activated potassium channel that contributes to the regulation of resting membrane potential and neuronal excitability. Unlike Slo1, Slo2.2 is activated by intracellular Na⁺ and Cl-, linking its activity to ionic homeostasis and metabolic state. This channel is thought to stabilize neuronal firing under conditions of high activity or metabolic stress, making it a potential modulator of excitotoxicity-a key feature of many neurodegenerative diseases. By dampening excessive excitability, Slo2.2 may protect neurons from calcium overload and oxidative damage. Although still under investigation, emerging evidence suggests that Slo2.2 dysfunction may contribute to the pathophysiology of epilepsy, ischemia, and neurodegenerative disorders such as ALS and Alzheimer's disease. Its unique activation profile and role in maintaining neuronal stability position Slo2.2 as a novel target for neuroprotective strategies.
- Versandbedingungen:
- Blue Ice