SMC-314
Nav1.7 Antibody, Clone N68/6
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SMC-314
- Zusätzliche Namen:
- Nav1.7, SCN9A, ETHA, hNE Na, NE NA, PN1, Voltage gated sodium channel subunit alpha Nav1, Peripheral sodium channel 1, Neuroendocrine sodium channel
- Anwendung:
- IHC, WB, IF, ICC, IP, Microarray
- Konzentration:
- 1 mg/ml
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Protein G Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- Host:
- Mouse
- Reaktivitäten:
- Hamster, Human, Mouse, Rat
- ABP:
- IMP-GEN-2015-06 < 10% Serum <100ml
- Buffer:
- PBS pH7.4, 50% glycerol, 0.09% sodium azide
- Immunogen:
- Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
- Klon:
- N68/6 (Formerly sold as S68-6)
- Uniprot:
- Q15858
- Synonyme:
- ETHA;FEB3B;GEFSP7;hNE-Na;HSAN2D;Nav1.7;NE-NA;NENA;neuroendocrine sodium channel;peripheral sodium channel 1;PN1;SFNP;sodium channel protein type 9 subunit alpha;sodium channel protein type IX subunit alpha;sodium channel, voltage-gated, type IX, alpha polypeptide;sodium channel, voltage-gated, type IX, alpha subunit;voltage-gated sodium channel alpha subunit Nav1.7;voltage-gated sodium channel subunit alpha Nav1.7
- Weitere Details:
- Nav1.7 is a voltage-gated sodium channel encoded by the SCN9A gene and is predominantly expressed in peripheral sensory neurons. It plays a pivotal role in pain perception by amplifying subthreshold stimuli and facilitating action potential initiation. Loss-of-function mutations in Nav1.7 result in congenital insensitivity to pain, while gain-of-function mutations are associated with chronic pain syndromes. Importantly, Nav1.7 is not expressed in cardiac or central neurons, making it an attractive target for pain therapeutics with minimal off-target effects. Although primarily studied in nociception, emerging research suggests that peripheral nerve dysfunction and chronic pain may contribute to neurodegenerative disease burden. Nav1.7 inhibitors are under investigation as next-generation analgesics with potential applications in neurodegenerative conditions involving neuropathic pain.
- Versandbedingungen:
- Blue Ice