Compound E

Eine Lieferung in diese Region ist nicht möglich.

SKU:: SIH-640
Zusätzliche Namen:: N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
Molekulargewicht:: 490.5
Reinheit:: ≥98%
Quelle:: Synthetic
Lagerbedingungen:: -20[o]C
Hersteller:: StressMarq Biosciences
CAS Number:: 209986-17-4
Weitere Details:: A highly potent, selective, and cell-permeable G Gamma-secretase inhibitor that blocks the proteolytic processing of both amyloid precursor protein (APP) and Notch, with IC₅₀ values of ~3 nM¹,². By inhibiting G Gamma-secretase-mediated cleavage of APP, the compound robustly suppresses amyloid-B Beta (AB Beta) production, a key pathological driver in Alzheimer's disease⁵. In neural systems, this inhibitor demonstrates broad neuroscience-relevant activity: it reduces proliferation and promotes differentiation of neuroblastoma cells³, and it induces neuronal differentiation from stem cells⁴, making it a valuable tool for studying neurodevelopment, neural lineage specification, and disease-associated signaling pathways.