SIH-422
6BIO
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SIH-422
- Zusätzliche Namen:
- (2'Z,3'E)-6-Bromoindirubin-3'-oxime, 6-BIO, 6BIO, (3Z)-6-Bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
- Molekulargewicht:
- 356.2
- Reinheit:
- ≥98%
- Quelle:
- Synthetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- CAS Number:
- 667463-62-9
- ABP:
- No Import Docs
- Weitere Details:
- 6BIO is a potent, reversible, and ATP-competitive inhibitor of glycogen synthase kinase-3A Alpha/B Beta (GSK-3A Alpha/B Beta), as well as an inhibitor of phosphoinositide-dependent kinase 1 (PDK1). Its ability to modulate the Wnt signaling pathway has made it a valuable tool in stem cell biology, particularly for maintaining self-renewal and pluripotency in embryonic stem cells. Although its primary applications have been in developmental biology and cancer research, emerging evidence suggests that GSK-3 inhibition may have neuroprotective effects. In the context of neurodegenerative diseases, 6BIO's modulation of GSK-3 activity could influence tau phosphorylation and amyloid precursor protein processing, both of which are implicated in Alzheimer's disease. This positions 6BIO as a compound of growing interest in neuroscience, particularly for its potential to modulate key signaling pathways involved in neuronal survival and plasticity.
- Versandbedingungen:
- Ambient