SIH-378
DAPT
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SIH-378
- Zusätzliche Namen:
- N-[(3,5-Difluorophenyl)acetyl]-L-al-anyl-2-phenyl]glycine-1,1-dimethylethyl ester
- Molekulargewicht:
- 432.46
- Reinheit:
- >99%
- Quelle:
- Synthetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- CAS Number:
- 208255-80-5
- ABP:
- No Import Docs
- Weitere Details:
- DAPT is a potent G Gamma-secretase inhibitor widely used in neuroscience and neurodegenerative disease research. By selectively reducing the production of amyloid-B Beta peptides AB Beta40 and AB Beta42-key contributors to Alzheimer's disease pathology-DAPT serves as a critical tool for studying amyloidogenic processing of amyloid precursor protein (APP). It effectively lowers AB Beta levels in human primary neuronal cultures and in vivo models, including brain, cerebrospinal fluid, and plasma, without altering non-amyloidogenic APPA Alpha and APPB Beta fragments. DAPT also inhibits Notch signaling, a pathway implicated in neural development and cell fate decisions. Its ability to promote neuronal differentiation makes it valuable for exploring neurogenesis and neural stem cell biology. DAPT is frequently cited in studies investigating the molecular mechanisms of Alzheimer's disease, neuroinflammation, and synaptic dysfunction.
- Versandbedingungen:
- Ambient