SIH-353
EX-527
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SIH-353
- Zusätzliche Namen:
- 6-Chloro-2,3,4,9-tetrahydro-1Hcarbazole-1-carboxamide (racemic)
- Molekulargewicht:
- 248.7
- Reinheit:
- >98%
- Quelle:
- Synthetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- CAS Number:
- 49843-98-3
- ABP:
- No Import Docs
- Weitere Details:
- EX-527 is a potent and selective SIRT1 inhibitor (IC₅₀ = 98 nM) that does not affect other sirtuins or HDACs. It increases p53 acetylation following DNA damage and is fully cell permeable. In neuroscience, EX-527 has been shown to promote neuronal differentiation from pluripotent stem cells and modulate neurogenesis-related transcription factors. Its ability to influence cell fate decisions and epigenetic plasticity makes it a valuable probe for studying neurodevelopment, cellular reprogramming, and SIRT1-linked pathways in neurodegenerative disease models.
- Versandbedingungen:
- Ambient