SIH-344
Nutlin-3
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- SIH-344
- Zusätzliche Namen:
- (+/-)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
- Molekulargewicht:
- 581.9
- Reinheit:
- >98%
- Quelle:
- Synthetic
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- StressMarq Biosciences
- CAS Number:
- 548472-68-0
- ABP:
- No Import Docs
- Weitere Details:
- Nutlin-3 is a potent and selective antagonist of MDM2 that inhibits the MDM2-p53 interaction (IC50 = 0.09 uM), leading to p53 stabilization and activation. It induces apoptosis and cell cycle arrest in cancer cells and has been widely used to study p53 signaling. In neuroscience, Nutlin-3 is of interest for its ability to modulate p53-dependent pathways involved in neuronal stress responses, DNA repair, and apoptosis. Its neuroprotective potential is being explored in models of stroke, neuroinflammation, and neurodegenerative diseases where p53 dysregulation contributes to pathology.
- Versandbedingungen:
- Ambient