KOA0854
Mouse CD5L ELISA Kit
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- KOA0854
- Zusätzliche Namen:
- AAC-11, AIM, API6, APOPTOSIS INHIBITOR 6, APOPTOSIS INHIBITOR OF MACROPHAGES, CD5 antigen like (scavenger receptor cysteine rich family), CD5 antigen-like, Cd5l, CD5L_HUMAN, CT 2, CT-2, Highly similar to ANTIGEN WC1.1 [Bos taurus], IgM associated peptide, IgM-associated peptide, Pdp, PRO229, SCAVENGER RECEPTOR CYSTEINE-RICH FAMILY, SP ALPHA, SP-alpha, Spalpha|CD5L
- Anwendung:
- ELISA
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Reaktivitäten:
- Mouse
- Immunogen:
- Expression system for standard: NSO; Immunogen sequence: E22-V352
- Spezies:
- Mouse
- Uniprot:
- Q9QWK4
- Synonyme:
- 1/6;A;AAC-;AAC-11;AI047839;AIM;AIM/Spalpha;Api6;apoptosis inhibitor 6;apoptosis inhibitor expressed by macrophages;Apoptosis inhibitory 6;CD5 antigen-like;CT-2;CT2;mAIM;Pdp;Pdp 1/6;Sp;Sp-alpha
- Weitere Details:
- CD5 antigen-like, also known as Sp alpha and AIM, is a protein that in humans is encoded by the CD5L gene. It is mapped to 1q21-q23 by fluorescence in situ hybridization. It is found that Aim expression is induced in mouse macrophages in response to loading with highly oxidized low density lipoprotein (oxLDL), and that Aim is expressed in foam cells within atherosclerotic lesions. Both the expression of Aim in lesions and its induction by oxLDL require Lxr /Rxr heterodimers. Aim-null macrophages are highly susceptible to oxLDL-induced apoptosis in vitro and undergo accelerated apoptosis in atherosclerotic lesions in vivo. Double knockout of Aim and Ldlr reduce atherosclerotic lesions. Therefore, it is concluded that AIM expression protects macrophages from apoptosis within atherosclerotic lesions, promoting early lesion development.
- Versandbedingungen:
- Blue Ice