KOA0830
Mouse Hemojuvelin ELISA Kit
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- KOA0830
- Zusätzliche Namen:
- DL M,HEMOCHROMATOSIS, HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN, HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE, HEMOCHROMATOSIS JUVENILE, Hemochromatosis type 2, Hemochromatosis type 2 protein, Hemochromatosis type 2 protein homolog, HEMOCHROMATOSIS TYPE 2A, HEMOCHROMATOSIS TYPE 2B, HFE2A, HJV, JH, Juvenile, Repulsive guidance molecule c, RGM C, RGM domain family member C, RGMC|HFE2
- Anwendung:
- ELISA
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Reaktivitäten:
- Mouse
- Immunogen:
- Expression system for standard: NSO; Immunogen sequence: Q33-D393
- Spezies:
- Mouse
- Uniprot:
- Q7TQ32
- Synonyme:
- 2310035L15Rik;5230400G09Rik;AI414844;AI789733;DL-;DL-M;hemochromatosis type 2 (juvenile) (human homolog);hemochromatosis type 2 protein homolog;hemoju;hemojuvelin;hemojuvelin BMP coreceptor;Hfe2;HJ;repulsive guidance molecule C;Rgm;RGM domain family member C;Rgmc
- Weitere Details:
- Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of a three gene family (in vertebrates) called the repulsive guidance molecules. In mouse, the Hemojuvelin protein is encoded by the HFE2 gene, and it is mapped to Chromosome 3. It was concluded that downregulation of hepatic Hemojuvelin during inflammation may induce a temporary elimination of iron sensing. Hemojuvelin is a coreceptor for bone morphogenetic proteins (BMPs), and inhibition of endogenous BMP signaling reduces hepcidin expression and increases serum iron in mice. Furthermore, Hemojuvelin may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion.
- Versandbedingungen:
- Blue Ice