KOA0509
Rat TrkA ELISA Kit
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- KOA0509
- Zusätzliche Namen:
- High affinity nerve growth factor receptor, MTC, Neurotrophic tyrosine kinase receptor type 1, NTRK1, NTRK1_HUMAN, Oncogene TRK, p140-TrkA, TRK, Trk-A, TRK1, TRK1-transforming tyrosine kinase protein|NTRK1
- Anwendung:
- ELISA
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Reaktivitäten:
- Rat
- Immunogen:
- Expression system for standard: NSO; Immunogen sequence: A33-P418
- Spezies:
- Rat
- Uniprot:
- P35739
- Synonyme:
- high affinity nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;neurotrophic tyrosine kinase, receptor, type 1;p140-TrkA;slow nerve growth factor receptor;Trk;trk-A;TrkA neurotrophin receptor;trkA proto-oncogene receptor;tropomyosin-related kinase A
- Weitere Details:
- Tropomyosin receptor kinase A(TrkA) are efficacious in attenuating skeletal pain.1 TrkA mutants were able to activate signaling cascades and were even more efficient in promoting neurite outgrowth than the wild-type receptor.2 TrkA is part of a sub-family of protein kinases which includes TrkB and TrkC. Also, there are other neurotrophic factors structurally related to NGF: BDNF(for Brain-Derived Neurotrophic Factor), NT-3(for Neurotrophin-3) and NT-4(for Neurotrophin-4). While TrkA mediates the effects of NGF, TrkB is bound and activated by BDNF, NT-4, and NT-3. Further, TrkC binds and is activated by NT-3.3 TrkA receptor was found in keratoconus-affected corneas, along with an increased level of repressor isoform of Sp3 transcription factor.4 The standard product used in this kit is extracellular part(A33-P418) of recombinant rat TRKA, consisting of 386 amino acids with the molecular weight of 69KDa.
- Versandbedingungen:
- Blue Ice