KOA0323
Mouse TNFR2 ELISA Kit
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- KOA0323
- Zusätzliche Namen:
- CD120b, Etanercept, p75, p80 TNF alpha receptor, TBP2, TBPII, TNF R2, TNFBR, TNFR-II, TNFR2, TNFRII, Tumor necrosis factor binding protein 2, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor superfamily member 1b, membrane form, Tumor necrosis factor receptor type II|TNFRSF1B
- Anwendung:
- ELISA
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Reaktivitäten:
- Mouse
- Immunogen:
- Expression system for standard: NSO; Immunogen sequence: V23-G258
- Spezies:
- Mouse
- Uniprot:
- P25119
- Synonyme:
- CD120b;p7;p75;p75 TNFR;p80 TNF-alpha receptor;TN;Tnf;TNF receptor beta chain;TNF-;TNF-a;TNF-alphaR2;TNF-R;TNF-R-II;TNF-R2;TNF-R75;TNF-RII;TNFal;TNFalpha-R2;TNFBR;TNFR;Tnfr-1;TNFR-II;Tnfr2;TNFR80;TNFRII;tumor necrosis factor receptor 2;tumor necrosis factor receptor superfamily member 1B;tumor necrosis factor receptor type II
- Weitere Details:
- Tumor necrosis factor receptor 2(TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors(TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12(12pter-cen) and 1(1pter-p32), respectively. TNFR2 was induced on glomerular endothelial cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essential for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-mediated glomerulonephritis.
- Versandbedingungen:
- Blue Ice