Mouse IGFBP-3 ELISA Kit

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SKU:: KOA0204
Zusätzliche Namen:: Acid stable subunit of the 140 K IGF complex, Binding protein 29, Binding protein 53, BP 53, BP53, Growth hormone dependent binding protein, IBP 3, IBP3, IGF binding protein 3, IGFBP 3, Insulin Like Growth Factor Binding Protein 3|IGFBP3
Anwendung:: ELISA
Lagerbedingungen:: Please refer to datasheet
Hersteller:: Rockland Inc
Reaktivitäten:: Mouse
Immunogen:: Expression system for standard: NSO; Immunogen sequence: G28Q-K291
Spezies:: Human
Uniprot:: B3KPF0
Synonyme:: acid stable subunit of the 140 K IGF complex;binding protein 29;binding protein 53;BP-53;growth hormone-dependent binding protein;IBP-3;IBP3;IGF-binding protein 3;IGFBP-3;insulin-like growth factor-binding protein 3
Weitere Details:: Insulin-like growth factor(IGF)-binding protein-3(IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. The circulating level of IGFBP-3 is inversely related to the risk of several common cancers, and that antiproliferative agents such as antiestrogens and retinoids act in part by up-regulating IGFBP-3 gene(IGFBP3) expression. Insulin-like growth factor-binding protein(IGFBP)-3, well characterized as the carrier of insulin-like growth factor(IGF), has been reported to have intrinsic bioactivity that is independent of IGF binding. IGFBP-3 has an IGF-independent, antiproliferative effect in undifferentiated and early differentiated but not in terminally differentiated chondrocytes. IGFBP-3 possesses both growth-inhibitory and potentiating effects on cells that are independent of IGF action and are mediated through specific. IGFBP-3 binding proteins/receptors locate at the cell membrane, cytosol, or nuclear compartments and in the extrIGFBP-3llular matrix. IGFBP3 is also located on chromosome 7. The standard product used in this kit is recombinant mouse IGFBP-3, consisting of 270 amino acids with the molecular mass of 29.4kDa. As a result of glycosylation, the molecular mass is 40-50KDa.

Versandbedingungen:: Blue Ice