Human GM-CSF ELISA Kit

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SKU:: KOA0182
Zusätzliche Namen:: Colony stimulating factor, Colony stimulating factor 2 (granulocyte macrophage), CSF, CSF 2, CSF2, GMCSF, Granulocyte macrophage colony stimulating factor, MGC141935, MGC138897, Molgramostin, Sargramostim|CSF2
Anwendung:: ELISA
Lagerbedingungen:: Please refer to datasheet
Hersteller:: Rockland Inc
Reaktivitäten:: Human
Immunogen:: Expression system for standard: E.coli; Immunogen sequence: A18-E144
Spezies:: Human
Uniprot:: P04141
Synonyme:: colony stimulating factor 2 (granulocyte-macrophage);Colony-stimulating factor;CSF;GMCSF;granulocyte macrophage-colony stimulating factor;granulocyte-macrophage colony-stimulating factor;molgramostim;molgramostin;sargramostim
Weitere Details:: Granulocyte-macrophage colony-stimulating factor(GM-CSF) is also symbolized CSF2. Human GM-CSF is a glycoprotein that is essential for the in vitro proliferation and differentiation of precursor cells into mature granulocytes and macrophages. The human cDNA clones contain a single open-reading frame encoding a protein of 144 amino acids with a predicted molecular mass of 16,293 daltons and show 69% nucleotide homology and 54% amino acid homology to mouse GM-CSF. The gene for human GM-CSF appears to exist as a single-copy gene. Human GM-CSF is a 22,000-dalton glycoprotein that stimulates the growth of myeloid progenitor cells and acts directly on mature neutrophils. The GM-CSF gene is localized by somatic cell hybrid analysis and in situ hybridization to human chromosome region 5q21-5q32, which is involved in interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. A complementary DNA for the T lymphocyte-derived lymphokine, GM-CSF has been cloned, and recombinant GM-CSF protein has been expressed in yeast and purified to homogeneity. This purified human recombinant GM-CSF stimulates peripheral blood monocytes in vitro to become cytotoxic for the malignant melanoma cell line A419.

Versandbedingungen:: Blue Ice