NMDA R2B phospho S1480 Antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 612-401-D93
Zusätzliche Namen:: Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b, NR3|Grin2b
Anwendung:: WB
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Rat
Lagerbedingungen:: Please refer to datasheet
Hersteller:: Rockland Inc
Host:: Rabbit
Reaktivitäten:: Mouse, Rat
Buffer:: 0.01 M HEPES, 0.15 M Sodium Chloride
Immunogen:: Anti-NMDA R2B pS1480 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1480.
Formulierung:: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Uniprot:: Q00960
Synonyme:: GluN2B;glutamate [NMDA] receptor subunit epsilon-2;glutamate receptor ionotropic, NMDA 2B;glutamate receptor, ionotropic, N-methyl D-aspartate 2B;glutamate receptor, ionotropic, NMDA2B;N-methyl D-aspartate receptor subtype 2B;NMDAR2B;NR2B
Weitere Details:: NMDA R2B pS1480 antibody detects rat NMDA 2B receptor protein. The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. It has been shown that phosphorylation of Ser1480 disrupts the interaction of NR2B with the PDZ domains of PSD-95 and SAP102 and decreases surface NR2B expression in neurons. Anti-NMDA R2B pS1480 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research.

Versandbedingungen:: Dry Ice