600-401-Y19
Anthrax Edema Factor Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-Y19
- Zusätzliche Namen:
- Anthrax Edema Factor Antibody, Calmodulin-sensitive adenylate cyclase, ATP pyrophosphate-lyase, EF, pxo1_122, Adenylyl cyclase, Anthrax edema toxin adenylate cyclase component, Edema factor, cya, pXO1-122, BXA0141, GBAA_pXO1_0142, Plasmid pXO1|cya
- Anwendung:
- ELISA
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Bacteria
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Bacteria
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Anthrax Edema Factor antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to 16 amino acids near the C-terminus of the Anthrax edema factor protein.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P40136
- Synonyme:
- Adenylyl cyclase;Anthrax edema toxin adenylate cyclase component;ATP pyrophosphate-lyase;Edema factor;pxo1_122;pXO1-122
- Weitere Details:
- Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++-dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system.
- Versandbedingungen:
- Dry Ice