ADAP Antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 600-401-X71
Zusätzliche Namen:: ADAP Antibody, ADAP, PRO0823, SLAP-130, SLAP130, FYN-binding protein, Adhesion and degranulation promoting adaptor protein, FYB-120/130, p120/p130, FYN-T-binding protein, SLP-76-associated phosphoprotein|FYB1
Anwendung:: ELISA, IHC, WB, IF
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-ADAP antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the N-terminus of human ADAP.
Formulierung:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: O15117
Synonyme:: ADAP;Adhesion and degranulation promoting adaptor protein;adhesion and degranulation-promoting adaptor protein;FYB;FYB-120/130;FYN-binding protein 1;FYN-T-binding protein;p120/p130;PRO0823;SLAP-130;SLAP130;SLP-76-associated phosphoprotein;THC3
Weitere Details:: The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.

Versandbedingungen:: Dry Ice