600-401-X18
Olig2 Phospho S10/13/14 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-X18
- Zusätzliche Namen:
- OLIG2|Oligodendrocyte transcription factor 2, Oligo2, Class B basic helix-loop-helix protein 1, bHLHb1, Class E basic helix-loop-helix protein 19, bHLHb19, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17
- Anwendung:
- ELISA, WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Mouse, Rat
- Buffer:
- 0.01 M HEPES, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Phospho-Ser10,13,14 Olig2 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser10,13,14 of human Olig2 conjugated to KLH.
- Formulierung:
- 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
- Uniprot:
- Q13516
- Synonyme:
- basic domain, helix-loop-helix protein, class B, 1;BHLHB1;bHLHe19;class B basic helix-loop-helix protein 1;class E basic helix-loop-helix protein 19;human protein kinase C-binding protein RACK17;OLIGO2;oligodendrocyte lineage transcription factor 2;oligodendrocyte transcription factor 2;oligodendrocyte-specific bHLH transcription factor 2;PRKCBP2;protein kinase C-binding protein 2;Protein kinase C-binding protein RACK17;RACK17
- Weitere Details:
- Olig2 is a well conserved bHLH transcription factor that shows both anti-neural functions and pro-neural functions at different stages in the formation of the oligodendrocyte lineage. Olig2 is expressed in 100% of the human diffuse gliomas irrespective of grade and required for intracranial tumor formation in a genetically relevant model of malignant glioma. A developmentally regulated triple serine motif at positions 10, 13 and 14 in the amino terminus is well conserved across species ranging from humans to zebrafish and is essential for Olig2 proliferative function in both normal and malignant neural progenitors. All three serine residues must be mutated to achieve a strong loss-of-function or gain-of-function phenotype, suggesting that the phosphorylation state of Olig2 represents a significant conformational change in the amino terminus. Olig2 pS 10/13/14 Antibody is ideal for researchers interested in neuroscience research.
- Versandbedingungen:
- Blue Ice