Slug Antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 600-401-H17
Zusätzliche Namen:: SLUG, SLUGH|SNAI2
Anwendung:: ELISA, WB, IF
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: Slug Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide from an internal region of human Slug.
Formulierung:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Uniprot:: O43623
Synonyme:: neural crest transcription factor SLUG;protein snail homolog 2;SLUG;slug (chicken homolog), zinc finger protein;SLUGH;SLUGH1;snail family zinc finger 2;snail homolog 2;SNAIL2;WS2D;zinc finger protein SNAI2
Weitere Details:: Slug antibody detects human Slug protein. Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophageal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein. Anti-Slug antibodies are ideal for investigators involved in transcription factors, cell cycle proteins and cancer research.

Versandbedingungen:: Dry Ice