600-401-ET6
SPP1 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-ET6
- Zusätzliche Namen:
- SPP1|SPP1 Antibody, OPN, BNSP, BSPI, ETA-1, OPN, PSEC0156, Osteopontin, Bone sialoprotein 1, SPP-1
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SPP1 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the N-terminus of human SPP1.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P10451
- Synonyme:
- BNSP;Bone sialoprotein 1;BSPI;early T-lymphocyte activation 1;ETA-1;nephropontin;OPN;osteopontin;osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein;Secreted phosphoprotein 1;secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1);secreted phosphoprotein 1 variant 6;SPP1/CALPHA1 fusion;urinary stone protein;uropontin
- Weitere Details:
- The secreted protein 1 (SPP1), also known as osteopontin, is a major noncollagenous protein of bone, but is also found in the extracellular matrix of other mineralized tissues and in bodily fluids. In bone, SPP1 is produced by osteoblasts, osteocytes, macrophages, and osteoclasts (1,2). SPP1 binds to cells through integrin and non-integrin receptors, as well as the adhesion receptor CD44 in an RGD-independent manner, enabling SPP1 to induce a number of functional effects including macrophage chemotaxis, cytoprotection, and regulation of T helper type 1 cells (2). SPP1 can regulate biomineralization by inhibiting the formation of hydroxyapatite (3) and the growth of calcium oxalate crystals (4).
- Versandbedingungen:
- Dry Ice