600-401-EP2
Slc35D1 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-EP2
- Zusätzliche Namen:
- SLC35D1|Slc35D1 Antibody, UGTREL7, KIAA0260, UGTREL7, Solute carrier family 35 member D1, UGTrel7
- Anwendung:
- ELISA, IHC, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Slc35D1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 20 amino acid synthetic peptide near the C-terminus of the human Slc35D1.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9NTN3
- Synonyme:
- SHNKND;solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1;solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1;Solute carrier family 35 member D1;UDP-galactose transporter-related 7;UDP-galactose transporter-related protein 7;UDP-GlcA/UDP-GalNAc transporter;UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter;UGTREL7
- Weitere Details:
- The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.
- Versandbedingungen:
- Dry Ice